A compilation of news articles in the field of gynecologic oncology and recent scientific studies
Pembrolizumab plus Lenvatinib active in endometrial cancer
July 6, 2018: Onc Live – “Updated phase Ib/II results of the combination of pembrolizumab (Keytruda) and lenvatinib (Lenvima) in patients with endometrial cancer were presented at the 2018 ASCO Annual Meeting” Read more.
‘Precision medicine’ needs rev up as genetic diversity grows
July 6, 2018: Bloomberg – “Drugmakers are feverishly investing in precision medicine as Americans develop increasingly complicated genetics thanks in part to the rising birth rates of children with multi-ethnic backgrounds.” Read more.
Ovarian suppression improves 8-year breast cancer survival
July 6, 2018: Healio – “The addition of ovarian suppression to tamoxifen lengthened OS and DFS among premenopausal women with breast cancer, according to updated findings from the TEXT and SOFT trials published in The New England Journal of Medicine.” Read more.
HPV test more effective than Pap smear in cancer screening, study suggests
July 3, 2018: CNN – “Cervical cancer is among the easiest gynecologic cancers to prevent, and two screening tests can help detect the disease early: the routine Pap smear and testing for human papillomavirus, or HPV.” Read more.
Study does not find causal association between assisted reproduction and ovarian cancer risk
July 3, 2018: NewsMedical.net – “Following concerns over many years that hormonal stimulation of the ovaries necessary for IVF may increase the risk of ovarian cancer, a nationwide cohort study from Denmark has now concluded that any perceived increase in risk is actually a statistical bias resulting from vigilant diagnosis at the time of treatment. The investigators were unable to make any causal association between the treatment and fertility drugs used and any excess risk of ovarian cancer.” Read more.
Endometriosis Not a Factor in Survival of Patients with Clear Cell Ovarian Cancer, Study Finds
June 28, 2018: Endometriosis News – “Endometriosis does not worsen or improve survival of patients with ovarian clear cell carcinoma, a study suggests. Researchers found that for these patients, resistance to treatment with platinum-based chemotherapy is the most important predictor of poor outcome.” Read more.
First-line olaparib prolongs PFS in BRCA-mutated ovarian cancer
June 27, 2018: Healio – “Frontline olaparib significantly improved PFS compared with placebo among women with BRCA-mutated advanced ovarian cancer, according to interim results from the SOLO-1 trial.” Read more.
Unraveling role of tumor suppressor in gene expression and ovarian tumorigenesis
June 26, 2018: Medical Express – “The tumor suppressor protein ARID1A controls global transcription in ovarian epithelial cells, according to new research conducted at The Wistar Institute, which provided mechanistic insight into tumorigenesis mediated by ARID1A loss in ovarian cancer. Study results were published online in Cell Reports” Read more.
As more women turn to genetic testing for breast cancer, understanding risk is key
June 25, 2018: The Washington Post – “The Food and Drug Administration not long ago announced its authorization that permits genetics testing company 23andMe to market a test for gene mutations associated with risk of breast and ovarian cancer.” Read more.
Fewer Genetic Testing Referrals for Minorities With Ovarian Cancer
June 25, 2018: Cancer Network – “Women of non-European ancestry and those enrolled in Medicare have lower rates of referral to genetic testing following an ovarian cancer diagnosis, researchers reported in Gynecologic Oncology.” Read more.
Is chemo obsolete? Not by a long shot, cancer experts say
June 24, 2018: NBC News – “Cancer therapy is being transformed as immune therapies, targeted treatments based on DNA profiles and personalized treatments make stunning advances in some patients. Could it mean an end to old-fashioned chemotherapy, the mainstay of cancer treatment for decades that’s dreaded by patients?” Read more.
Automated approach may improve cervical cancer screening
June 22, 2018: Healio – “An automated risk score algorithm of cervical screening and triage demonstrated similar sensitivity and specificity to cytology for targeting precancerous conditions and identifying women with HPV most in need of treatment, according to study findings.”Read more.
Can anxiety and early life adversity affect ovarian cancer outcomes?
June 21, 2018: Cancer Network – “In women with a recent ovarian cancer diagnosis, decreased anxiety was found to be associated with better regulated cortisol profiles, according to a new study. Those with early life adversity and other factors associated with anxiety had sustained anxiety and more dysregulation of cortisol, suggesting they may be at risk for more negative outcomes.”Read more.
Defining imaging’s role in the treatment of cervical, endometrial cancers
June 19, 2018: Radiology Business – “Though not often the first line of defense, clinicians should consider endometrial cancer screening using either CT or MRI after a patient undergoes radiation therapy for cervical carcinoma, Portuguese researchers argue in the first-ever study published on the subject.” Read more.
Ovarian cancer cells switched off by ‘unusual’ mechanism
June 19, 2018: MedicalXpress – “Scientists at the Ovarian Cancer Action Research Centre at Imperial College London have discovered a mechanism that deactivates ovarian cancer cells. The findings, published in EMBO Reports, could lead to better treatments for women with ovarian cancer. The research has found a new mechanism for a protein named OPCML. This protein is known as a tumour suppressor, as it prevents cells turning cancerous.” Read more.
FDA Approves Avastin Plus Chemo for Certain Women With Advanced Ovarian Cancer
June 18, 2018: Clinical Oncology – “The FDA granted a new indication for bevacizumab (Avastin, Genentech) in combination with chemotherapy (carboplatin and paclitaxel), followed by bevacizumab as a single agent, for the treatment of women with advanced ovarian cancer after initial surgical resection.” Read more.
Chemoradiation prevails in cervical cancer trial
June 15, 2018: MedPage Today – “Patients with locally advanced cervical cancer had significantly increased disease-free survival (DFS) when treated with chemoradiation instead of neoadjuvant chemotherapy followed by radical surgery, a large randomized trial showed.” Read more.
Study opens new potential avenue for treating ovarian cancer
June 14, 2018: News Medical Life Sciences – “Researchers at Houston Methodist Research Institute and The University of Texas MD Anderson Cancer Center have found a prescription drug, Calcitriol, approved by the Food and Drug Administration for the treatment of calcium deficiency and kidney diseases, may increase the likelihood of surviving ovarian cancer.” Read more.
FDA grants priority review to Gardasil 9 for adults aged 27 to 45
June 13, 2018: Healio – “The FDA granted priority review to a supplemental biologics license application that seeks approval of the HPV 9-valent vaccine, recombinant, for use among women and men aged 27 to 45 years for the prevention of HPV-related cancers.” Read more.
ASCO Clinical Practice Guideline focused update: selection of optimal adjuvant chemotherapy and targeted therapy for early breast cancer
June 13, 2018: ASCO Post – “ASCO has issued a focused update on the clinical practice guideline on optimal chemotherapy and targeted therapy in early breast cancer.” Read more.
FDA approves Avastin plus chemotherapy for ovarian cancer after surgery
June 13, 2018: Healio – “The FDA approved bevacizumab for use with chemotherapy, followed by bevacizumab as a single agent, for the treatment of women with advanced ovarian cancer who underwent initial surgical resection.” Read more.
A new way to classify endometrial cancer
June 12, 2018: Ob.Gyn.News – “This column will explore the newer, more sophisticated molecular-based classifications that are being validated for endometrial cancer, and the ways in which this promises to personalize the treatment of endometrial cancer.” Read more.
FDA approves Keytruda for cervical cancer
June 12, 2018: Healio – “The FDA expanded the approval of pembrolizumab to include the treatment of women with recurrent or metastatic cervical cancer who have PD-L1-expressing tumors that progressed on or after chemotherapy.” Read more.
Clinical Challenges: Surgery’s Role in Recurrent Ovarian Cancer
June 12, 2018: Med Page Today -“The debate over repeat surgery for recurrent, platinum-sensitive ovarian cancer remains an open one, as studies reported over the past year produced disparate results.” Read more.
NCI cancer centers endorse goal of eliminating HPV cancers
June 11, 2018: Infectious Disease Advisor – “National Cancer Institute (NCI)-designated cancer centers are endorsing the goal of eliminating cancers caused by the human papillomavirus (HPV) through HPV vaccination and evidence-based cancer screening, according to a statement from the American Cancer Society and other organizations.” Read more.
Clinical Challenges: Few Options for Advanced Cervical Cancer
June 8, 2018: MedPage Today – “Recent progress in the treatment of cancer has not had a major impact on outcomes in advanced forms of cervical cancer. Increased emphasis on screening for human papillomavirus (HPV) — which causes almost all cervical cancers — has led to diagnosis of most cases of the disease at an early, curable stage. However, the prognosis remains grim for women with recurrent, persistent, or metastatic cervical cancer, associated with a 5-year survival rate of only 5-15%.” Read more.
Researchers: Off-label cancer treatment recommendations often based on weak evidence
June 8, 2018: Healio – “National Comprehensive Cancer Network guidelines frequently recommends that newer branded drugs be used in settings beyond their FDA-approved indications, according to results of a retrospective, observational study published in The BMJ.” Read more.
Secondary surgery fails to improve outcomes in recurrent ovarian cancer
June 7, 2018: Cancer Network – “Secondary cytoreductive surgery was not associated with improvement in either overall survival (OS) or progression-free survival (PFS) over no surgery in patients with platinum-sensitive recurrent ovarian cancer. ” Read more.
MD Anderson and nation’s top cancer centers endorse goal of eliminating HPV-related cancers
June 7, 2018: Phys.org – “Recognizing that vaccination rates for the human papillomavirus (HPV) remain low across the U.S., particularly in Texas, The University of Texas MD Anderson Cancer Center again has joined with the 69 other National Cancer Institute (NCI)-designated cancer centers in issuing a joint statement to call for increased HPV vaccination and evidence-based screening, with the goal of eliminating cancers caused by the virus.” Read more.
New drug combination shows promise in treating ovarian cancer
June 06, 2018: University of Kansas Cancer Center News “Researchers at The University of Kansas Cancer Center have discovered a therapy combination that may be helpful in the treatment of certain types of ovarian cancer.” Read more.
Vaginal bacteria may have a role in cervical cancer
June 6, 2018: Medical News Today – “The composition of bacteria in the vagina could be an important factor in the development of cervical cancer, according to a recent study.” Read more.
2018 ASCO Annual Meeting
June 5, 2018: Targeted Oncology – “The ASCO Conference Coverage page at Targeted Oncology is a full-service resource center for the latest from ASCO 2018, including key developments from presentations pertaining to breast cancer, lung cancer, and other cancer types.” See more.
Results from Genelux Corporation’s Phase 1b Trial of GL-ONC1 in Recurrent Ovarian Cancer to be presented at the ASCO Annual Meeting 2018
June 4, 2018: PRNewswire – “GL-ONC1 demonstrated a favorable safety profile and clinical benefits, which support further investigation in its ongoing Phase 2 VIRO-15 Study: Oncolytic Vaccinia Immunotherapy in Recurrent Ovarian Cancer. ” Read more.
New approach to immunotherapy leads to complete response in breast patient unresponsive to other treatments
June 4, 2018: NIH – “A novel approach to immunotherapy developed by researchers at the National Cancer Institute (NCI) has led to the complete regression of breast cancer in a patient who was unresponsive to all other treatments.” Read more.
Platinum-based neoadjuvant chemotherapy in triple-negative breast cancer: a systematic review and meta-analysis
June 4, 2018: Annals of Oncology – “Background: The role of platinum-based neoadjuvant chemotherapy in triple-negative breast cancer (TNBC) patients is highly controversial and it is not endorsed by current guidelines. Our meta-analysis aimed to better elucidate its activity, efficacy and safety.” Read the article.
Improving Global Health Through Local Partnerships
June 4, 2018: Linked In – Executive Director of Health Volunteers Overseas (HVO), Nancy Kelly discusses the 71st World Health Assembly and HVO’s role and contributions to increasing health security and improved health outcomes across the globe. Read her blog.
Are We Really Prepared for the Genetic Revolution?
May 27, 2018: Scientific American – “Genetic data could lead to more personalized, meaningful education, but only if parents, teachers and policymakers understand genetics well enough to correctly use the information.” Read more.
Rapid response to HPV vaccination crisis in Ireland
May 26, 2018: The Lancet – This article discusses the school-based HPV vaccination program in Ireland implemented in 2010 and recent statistics. Read the article.
Laparoscopic surgery for gynecologic cancer in low- and middle-income countries (LMICs): An area of need
May 2018: Gynecologic Oncology: “Highlights: Increasing surgical capacity in LMICs is imperative to improving global health and treatment of gynecologic cancers. Laparoscopic surgery for gynecologic cancer in LMICs is limited and has added benefits specific to LMICs. Barriers to implementing laparoscopic surgical techniques in LMICs should be identified and addressed.” Read the article.
Splash pharmaceuticals announces dose escalation in phase I clinical trial in platinum-resistant ovarian cancer patients
May 25, 2018: Pipeline Review – ” Splash announced the successful completion of the first safety cohort of patients and initiation of dose escalation in its ongoing clinical trial in platinum-resistant ovarian cancer patients. The Phase I trial is being conducted at Rutgers Cancer Institute of New Jersey, a National Cancer Institute-designated Comprehensive Cancer Center.” Read the press release.
Dr. Cohen on the evolution of surgery in ovarian cancer
May 25, 2018: Onc Live – “Joshua G. Cohen, MD, assistant professor, Division of Gynecologic Oncology, University of California, Los Angeles, discusses the evolution of surgery in the treatment of patients with ovarian cancer.” See more.
CDC announces review of pre-op diagnosis of uterine cancers by gynecologists
May 25, 2018: Cancer Letter – “Robert Redfield, director of the Centers for Disease Control and Prevention, said the agency is reviewing the methods gynecologists use to identify women at risk of uterine cancers.” Read more.
Precision Medicines Approved More Quickly, With Less Data
May 25, 2018: MedPage Today – “Precision medicines are approved more quickly and on the basis of fewer patients and smaller pivotal trials than nonprecision medicines, according to a study in Health Affairs analyzing nearly 5 years of recent FDA data.” Read more.
Survey: Patients are ill-informed about precision medicine
May 24, 2018: FierceHealthcare – “Many patients are unfamiliar with precision medicine, but when they’re educated on what genomics can do, they’re excited about the possibilities it creates for their care, according to a new survey. “Read more.
Secondary Surgery Associated With Improved Survival in Ovarian Cancer
May 23, 2018: Cancer Network – “A secondary cytoreductive surgery along with chemotherapy following recurrence in patients with epithelial ovarian cancer offered improved outcomes over treatment with chemotherapy alone, according to a new study.” Read more.
Gynecology’s deadly surprise: Cancers are frequently missed prior to routine procedures
May 18, 2018: The Cancer Letter – “As they reach for surgical tools, gynecologists vastly underestimate the probability that their patients have undiagnosed uterine cancers, a study by Yale University researchers found. Their paper, published in Obstetrics & Gynecology last month, is immediately relevant in the clinic, because a suspicion that cancer may be present dictates the choice of surgical techniques employed in gynecological procedures that are performed in about 650,000 women every year in the United States.” Read more.
Endometriosis raises risk of ovarian cancer but not other gynecological cancers, study suggests
May 17, 2018: Endometriosis News – “In line with previous data, the researchers found that endometriosis was associated with an increased risk of ovarian cancer. In particular, these women were found to have a 3.12 times higher incidence of the endometrioid type of ovarian cancer and a 5.17 times higher incidence of the clear cell type than the general female population.” Read more.
Mayo discovery could enable development of personalized ovarian, brain cancer treatments
May 17, 2018: News Medical Life Sciences – “Mayo Clinic researchers have discovered that a molecular communication pathway – thought to be defective in cancer – is a key player in determining the effectiveness of measles virus oncolytic cancer treatment in ovarian and aggressive brain cancers. This discovery enabled researchers to develop an algorithm to predict treatment effectiveness in individual patients. The findings appear in the Journal of the National Cancer Institute.” Read more.
Ovarian cancer patients may benefit from Trabectedin with PLD
May 16, 2018: Clinical Advisor – “Trabectedin with pegylated liposomal doxorubicin (PLD) may provide long-term benefits for pre-treated patients with platinum-sensitive recurrent ovarian cancer (ROC), according to a study published in the Journal of Cancer Research and Clinical Oncology.” Read more.
Multi-epitope T-cell vaccine shows promise in ovarian, breast cancer
May 16, 2018: Cancer Network – “Investigators at the Mayo Clinic report that a vaccine is showing benefit in combating ovarian cancer in women who have suffered recurrence following successful platinum-based therapy.”Read more.
Study finds more isn’t better for Roche breast cancer drug
May 16, 2018: Bloomberg – “According to research released Wednesday, women taking Herceptin for six months were just as likely to be free of cancer four years later as those who used the drug for a year, the current standard of care recommended by the U.S. Food and Drug Administration and Roche.” Read more.
HPV vaccines protect against precancerous cervical lesions
May 16, 2018: Medscape – “Vaccination against the human papillomavirus (HPV) is highly protective against precancerous cervical lesions in adolescents and young women compared with placebo, especially those who are negative for HPV at the time of vaccination, a systematic Cochrane review concludes.” Read more.
Palliative care in the global setting: ASCO Resource Stratified Practice Guideline
May, 2018: JGO – “The purpose of this new resource-stratified guideline is to provide expert guidance to clinicians and policymakers on implementing palliative care of patients with cancer and their caregivers in resource-constrained settings and is intended to complement the Integration of Palliative Care Into Standard Oncology Care: American Society of Clinical Oncology Clinical Practice Guideline Update of 2016.” Read the article.
Oncologic and palliative care in a global setting in the twenty-first century: the patient, family, and oncologic health care team
May, 2018: JGO – “Palliative care in oncology is a crucial issue and unmet need across the spectrum of cancer care and in countries and communities with varying degrees of resource allocation for cancer care. ” Read the article.
Cancer treatment during pregnancy has increased, may cause neonatal complications
May 14, 2018: Healio – “Researchers reported that newborns exposed to antenatal chemotherapy may be at increased risk for being small for gestational age and for admittance to the NICU compared with other newborns.” Read more.
CVD risk elevated in endometrial ca survivors
May 13, 2018: “Endometrial cancer survivors, especially those who are obese, older, or treated with adjuvant radiotherapy and/or chemotherapy, are at significantly increased risk of adverse cardiovascular outcomes compared with women in the general population, researchers found.” Read more.
Scientists identify why some people may be resistant to PARP inhibitor drugs
May 10, 2018: Forbes – “A team of scientists from the Institute of Cancer Research in London has identified DNA mutations which makes cancer cells resistant to a new class of drugs called PARP inhibitors, used for the treatment of breast and ovarian cancers.” Read more.
Global analysis confirms HPV vaccine prevents cervical precancer
May 9, 2018: Healio – “HPV vaccination prevented cervical lesions among young women, particularly those vaccinated when aged 15 to 26 years, according to a metanalysis of 26 studies published in Cochrane Library.” Read more.
Why ovarian cancer spreads and how we might stop it
May 9, 2018: Medical News Today – “New research has revealed exactly why ovarian cancer spreads to the peritoneal cavity. Existing drugs could be repurposed to stop this from happening.” Read more.
Cyclophosphamide-Bevacizumab as Second-Line Chemo in Advanced Recurrent Cervical Cancer
May 7, 2018: Center for Biosimilars News “Some cervical cancer patients with advanced or recurrent disease suffer from anaphylaxis after taxane- or platinum-based therapy, and there is no standard treatment for progressive disease that develops during or shortly after platinum-based chemotherapy. Doctors and patients have therefore sought the development of a non-taxane, non-platinum regimen for recurrent cervical cancer.” Read more.
Pill may be better than mammograms at diagnosing breast cancer
May 2, 2018: FIGO – “Researchers from the University of Michigan in the US have developed a new method of diagnosing breast cancer that may be significantly more effective than mammograms. The team at the university has been working on a pill that will make tumours light up when exposed to infrared light, with this test having been demonstrated in the laboratory on mice. It works by using a dye that will show up under the light when it encounters a molecule found in cancerous cells.” Read more.
ASBrS 2018: breast cancer genetic testing guidelines exclude almost half of high-risk patients
May 5, 2018: ASCO Post – “Current restrictive genetic testing guidelines exclude many patients who harbor high-risk breast cancer mutations, according to two new studies presented at the American Society of Breast Surgeons (ASBrS) 19th Annual Meeting.”Read more.
New data prompts CDC to examine adequacy of pre-op work up by gynecologists
May 4, 2018: Cancer Letter – “In response to a congressional letter and a new study on the prevalence of undiagnosed hidden uterine cancers, officials at the Centers for Disease Control and Prevention are considering launching a review of whether gynecologists are sufficiently thorough in evaluating patients in the preoperative setting, according to insiders with knowledge of the agency’s plans.” Read more.
Approaching a case of stage 3C ovarian cancer
April 30, 2018: “Expert Robert L. Coleman, MD, reviews the case of a 38-year old woman who presents with stage 3 epithelial ovarian cancer.” Read more.
Carboplatin in BRCA1/2-mutated and triple-negative breast cancer BRCAness subgroups: the TNT Trial
April 30, 2018: Nature Medicine – “We conclude that patients with advanced TNBC benefit from characterization of BRCA1/2mutations, but not BRCA1 methylation or Myriad HRD analyses, to inform choices on platinum-based chemotherapy. Additionally, gene expression analysis of basal-like cancers may also influence treatment selection.” Read more.
Genetic testing, treatment advances offer ‘hope on the horizon’ for ovarian cancer
April 28, 2018: Cure – “The most exciting thing for us right now is being able to identify these genes that increase your risk, being able to implement appropriate screening procedures, doing the surgery and the cascade testing, and preventing these diseases from even occurring.” Read more.
Ovarian cancer dream team helps with genetic testing process
April 28, 2018: Cure – “A new study may help make the genetic testing process more convenient in real-time, according to Stephanie V. Blank, M.D., of director of gynecologic oncology at the Icahn School of Medicine at Mount Sinai.” Read more.
Size matters when fighting cancer
April 27, 2018: Science Daily – “Doctors could be a step closer to finding the most effective way to treat cancer with a double whammy of a virus combined with boosting the natural immune system, according to a pioneering study.” Read the article.
ESTRO 37: Brachytherapy for patients with cervical cancer does not increase risk of ureteral stricture
April 27, 2018 – “A rare but potentially serious complication following radiation treatment for cervical cancer is a narrowing of the tube that takes urine from the kidneys to the bladder (the ureter), which can lead to kidney damage and sometimes life-threatening infections. ” Read more.
Cancer is causing complications
April 25, 2018: Healthline – “Many women are experiencing severe and long-lasting side effects after getting a LEEP. So why isn’t the medical community listening?” Read more.
High-grade endometrioid endometrial cancers likely to benefit from immunotherapy
April 24, 2018: Cure – “Researchers evaluates microsatellite instability-high status, tumor mutation burden and high PD-L1 expression to determine which grade of tumors would benefit from immunotherapy treatment among women with endometrioid endometrial cancer.” Read more.
How working dogs are sniffing out cancer
April 21, 2018: Penn Today – At the University of Pennsylvania, dogs have been trained to detect early stage ovarian cancer using plasma samples. This research could translate to a device that could be used in a clinic. Read more.
Researchers seek to improve early cancer detection with gene-based tests
April 20, 2018: Oncology Times – “The key to reducing cancer deaths is early detection. Researchers at the Johns Hopkins Kimmel Cancer Center in Baltimore are exploring how to use cancer gene discoveries to develop screening assays to improve survival rates among cancer patients.” Read the article.
Dr. Monk of combination therapies in patients with ovarian cancer
April 19, 2018: Onc Live – “These signals are now translating into larger randomized trials with the potential for accelerated FDA approvals. Bringing checkpoint inhibitors to the clinic for patients with advanced or recurrent ovarian cancer has garnered much excitement to the field.” See more.
Diet linked with tumor aggressiveness in endometrial cancer
April 19, 2018: Onc Live – “The obese state of mouse models was shown to promote tumor aggressiveness in endometrial cancer, according to Lindsay West, MD.” See more.
Sedentary lifestyle drastically increases risk of dying from cancer
April 18, 2018: NewsWise – “One of the most striking observations was that previously inactive patients who began exercising after their diagnosis increased their odds of survival by nearly 30%.” Read more.
Study assesses immunotherapies for precancerous cervical lesions, advanced disease
April 18, 2018: Healio – “Researchers at USC Norris Comprehensive Cancer Center are conducting two clinical trials designed to investigate a form of immunotherapy for patients at both the precancerous and most advanced stage of cervical cancer.” Read more.
Pre-clinical data demonstrating promising potential of prexigebersen as treatment for solid tumors in gynecologic malignancies presented at American Association for Cancer Research Annual Meeting
April 18, 2018: Kaplan Herald – “The data showed there was an eighty-six percent (86%) decrease in tumor burden (p<0.05), and multinodular burden (p<0.01) in the combination prexigebersen/paclitaxel group compared to control. In addition, there was no apparent toxicity with mice on combination therapy losing less weight than the paclitaxel-only group (P = 0.005).” Read more.
What’s the latest in immunotherapy for gynecologic cancers?
April 18, 2018: Dana Farber – In a recent Facebook Live chat, Ursula Matulonis, MD, director of Gynecologic Oncology at Dana-Farber Cancer Institute, discussed the research advances, relevant clinical trials, and the excitement around the use of immunotherapy and its approaches for treating all gynecologic cancer. See more.
Study finds relationship between PTEN loss, potential for immune response in BRCA 1/2-deficient ovarian cancer
April 16, 2018: Medical XPress – “The protein known as phosphatase and tensin homolog (PTEN) is frequently mutated or affected by cancer as tumors develop. Now a new study shows PTEN may serve as a marker for whether a patient with BRCA 1-2 deficient ovarian cancer is likely to respond to checkpoint inhibitor therapy.” Read more.
Taselisib monotherapy appears active in PIK3CA-mutated solid tumors
April 15, 2018: Healio – “Taselisib demonstrated preliminary clinical activity and exhibited an acceptable safety profile as monotherapy for patients with PIK3CA-mutated locally advanced or metastatic solid tumors.” Read more.
Automated screening for cervical cancer is fast and accurate
April 13, 2018: Everyday Health – “The most important thing is they are automating the Pap test read, which means that it would allow for high-quality Pap tests everywhere, especially for parts of the world where Pap tests aren’t available because there isn’t anyone available to read them accurately.” Read more. See another article from MedPage Today
Advanced ovarian cancer survival rates longer after primary cytoreductive surgery compared with neoadjuvant chemotherapy
April 12, 2018: Clinical Advisor – Primary cytoreductive surgery (PCS) is associated with a longer survival rate compared with neoadjuvant chemotherapy (NACT) in patients with stage IIIC and IV high-grade serous ovarian carcinoma (HGSC), according to a study published in the International Journal of Gynecological Cancer. Read more.
A personalized vaccine helps patients fight back against ovarian cancer
April 12, 2018: LA Times – “Because the treatment uses the patient’s immune cells as a sort of T-cell training force, it is an immunotherapy. Because it uses the distinctive proteins on a patient’s own tumor as homing beacons, it is a targeted therapy. And because a patient’s own cells are harvested and returned to her, it is personalized therapy.” Read more.
Genomic analysis of 33 cancer types completed
April 10, 2018: NIH – “Cancer is caused by changes to DNA that affect the way cells grow and divide. There are at least 200 forms of cancer, with many subtypes. Identifying the changes in each cancer’s complete set of DNA—its genome—and understanding how these changes interact to drive the disease will lay the foundation for improving cancer prevention, early detection, and tailored treatments.” Read more.
FDA approves rucaparib for maintenance in recurrent ovarian cancer
April 7, 2018: AMJC – “FDA on Friday approved rucaparib, sold by Clovis Oncology as Rubraca, for maintenance treatment of adult patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer.” Read more.
Matulonis highlights early promise seen with pembrolizumab/mirvetuximab soravtansine combo in ovarian cancer
April 6, 2018: Targeted Oncology – “According to initial results presented at the 2018 Society of Gynecologic Oncology (SGO) Annual Meeting, 43% of the first 14 patients with platinum-resistant epithelial ovarian cancer treated with the combination of pembrolizumab (Keytruda) and mirvetuximab soravtansine (IMGN853), a folate receptor-alpha antibody drug conjugate (ADC), had partial responses.” Read more.
Study: No increased risk of serious AEs with combined urogyn/gyn onc surgery
April 4, 2018: MDEdge – “Intraoperative and serious postoperative adverse events do not occur more frequently with concurrent urogynecologic and gynecologic oncology procedures versus the latter alone, but minor adverse events are more common, according to findings from a retrospective matched cohort study.” Read more.
PARP-7 mutation associated with longer ovarian cancer survival
April 4, 2018: Healio – “Patients with ovarian cancer with gene amplification of the PARP-7 protein had longer OS than patients without it, suggesting the protein may play an important role in survival, according to study results presented at the Society of Gynecologic Oncology Annual Meeting on Women’s Cancer.” Read more.
Experimental gene test shows promise for early detection of gynecologic cancers
April 4, 2018: Genomic – “Adding DNA collection to the routine Pap test may improve cancer diagnoses.” Read more.
Obese, overweight women at increased risk for cervical cancer
April 3, 2018: Healio – “Women with overweight and obesity had a higher risk for cervical cancer, but lower rates of cervical precancer, according to a retrospective analysis published in Journal of Clinical Oncology.” Read more.
Participation in clinical trials may eliminate ovarian cancer survival disparities
April 2, 2018: Healio – “Improving the diversity of enrollment in clinical trials may improve health disparities among women with ovarian cancer, according to study results presented at the Society of Gynecologic Oncology Annual Meeting on Women’s Cancer.” Read more.
Double mastectomy may reduce risk for cancer, death among BRCA1 carriers
April 2, 2018: Healio – “Healthy women who carried the BRCA1 mutation had reduced risk for developing breast cancer and mortality if they underwent bilateral risk-reducing mastectomy, according to results of a prospective study presented at the European Breast Cancer Conference.” Read more.
Potential of manipulating gut microbiome to boost efficacy of cancer immunotherapies
April 2, 2018: Science Daily – “The composition of bacteria in the gastrointestinal tract may hold clues to help predict which cancer patients are most apt to benefit from the personalized cellular therapies that have shown unprecedented promise in the fight against hard-to-treat cancers.” Read more.
Only certain gynecologic malignancies benefit from immunotherapy
April 2, 2018: Cure Today – “Certain histologies may be better suited for immunotherapy treatment compared with others – all determined by microsatellite instability-high (MSI-H) status, tumor mutation burden (TMB) and PD-L1 expression.” Read more.
SGO 2018: immunotherapy/PARP inhibitor combination produces remissions in ovarian cancer
March 30, 2018: ASCO Post – “A combination of the immunotherapy pembrolizumab (Keytruda) and the DNA repair–blocking agent niraparib (Zejula) can be significantly more effective than either drug alone in women with hard-to-treat ovarian cancer, a phase I/II clinical trial led by Dana-Farber Cancer Institute researchers demonstrated. The investigators presented their findings at the Society of Gynecologic Oncology (SGO) Annual Meeting on Women’s Cancer.” Read more.
Does Trastuzumab plus Carbo/Paclitaxel Up PFS in advanced HER2+ uterine carcinoma?
March 30, 2018: Cancer Network – The addition of trastuzumab to the combination of carboplatin and paclitaxel was well tolerated among women with advanced or recurrent uterine serous carcinoma (USC) tumors that overexpress the tyrosine kinase human epidermal growth factor receptor 2 (HER2/neu)” Read more.
Combined PARP, checkpoint inhibitor regimens show ovarian cancer activity
March 29, 2018: Ob Gyn News – “Results from the first two trials to assess the efficacy of combined treatment with a PARP inhibitor plus an immune checkpoint inhibitor in patients with ovarian cancer showed promising results in both phase 2.” Read more.
Lower leg lymphedema common after gyn surgery
March 29, 2018: MedPage Today – “Approximately 20-40% of women have significant lower-extremity lymphedema after surgery for gynecologic cancer, according to data from the most comprehensive study of the issue to date.” Read more.
Targeted combo active in advanced ovarian combo
March 28, 2018: MedPage Today – “The combination of a PARP inhibitor and a PD-1/PD-L1 inhibitor proved active in different populations of recurrent ovarian cancer, according to results of two preliminary clinical studies reported here at the Society of Gynecologic Oncology meeting.” Read more.
Nearly one-in-five women with cervical cancer are diagnosed after age 65
March 28, 2018: Cancer Network – “Statistically controlling for hysterectomies revealed that cervical cancer rates are higher among women older than 65.” Read more.
Mutant protein linked to ovarian cancer could be new treatment target
March 28, 2018: UPI – “Researchers have found a mutant protein that is linked to ovarian cancer growth, prompting the possibility of new drugs to target this regulator.” Read more.
Promise seen with frontline pembrolizumab plus chemotherapy in ovarian cancer
March 28, 2018: Targeted Oncology – “The combination of first-line platinum-containing chemotherapy plus the anti-PD-1 agent pembrolizumab (Keytruda), followed by pembrolizumab maintenance therapy, was safe and tolerable in patients with advanced ovarian cancer, according to preliminary data from a small clinical trial presented at the 2018 Society of Gynecologic Oncology Annual Meeting.” Read more.
Unexpected outcome in hysterectomy study
March 27, 2018: MedPage Today – “Women undergoing radical hysterectomy for early cervical cancer had a significantly higher risk of disease recurrence and worse long-term survival with minimally invasive surgery (MIS), including robotic-assisted procedures, two separate studies showed.” Read more.
In relapsed ovarian cancer, responses achieved with PARP/checkpoint inhibitor combo
March 27, 2018: Targeted Oncology – “According to results from the phase II MEDIOLA trial, the combination of olaparib (Lynparza), a PARP inhibitor, and durvalumab (Imfinzi), a PD-L1 inhibitor, was found to induce objective responses in over 70% of patients with relapsed, platinum-sensitive, BRCA-mutated ovarian cancer.” Read more.
Analysis comparing PARP inhibitors in ovarian cancer
March 27, 2018: Targeted Oncology – “The results of a network meta-analysis, which compared efficacy and safety findings from studies of 3 FDA-approved PARP inhibitors as maintenance therapy for patients with relapsed platinum-sensitive ovarian cancer, demonstrated that similar efficacy results were seen across the 3 PARP inhibitors, but safety results differed. ” Read more.
Indocyanin green improves sentinel node detection in uterine malignancies
March 25, 2018: Cancer Therapy Advisor – “For this prospective study, researchers randomly assigned 180 patients with cervical or uterine cancers to undergo intraoperative cervical injection with isosulfan blue followed by ICG or vice versa.” Read more.
Recurrent endometrial ca responds to mTOR drug
March 25, 2018: Med Page Today – “Combination therapy with everolimus (Afinitor) and letrozole (Femara) demonstrated encouraging activity in recurrent endometrial cancer, particularly in patients with no prior chemotherapy, according to a randomized trial reported here.” Read more.
The new HPV vaccination policy in France
March 22, 2018: NEJM – “This change in policy has two goals. The first is to dispel the ambiguity in decision making between mandatory and recommended vaccinations; this ambiguity may partly explain the lower vaccination coverage in France than in its European neighbors and in much of the world. The second goal is to reconcile the general population in France to the use of vaccines at a time when the level of confidence in them here is among the lowest anywhere.” Read more.
Palliative care program development in a low- to middle-income country: delivery of care by nongovernmental organization in India
March, 2018: Journal of Global Oncology – Demand for palliative care services has increased substantially, with an increasing proportion related to cancer. The organization of clinical services by TIPS may serve as a model for the development of other palliative care programs in low- and middle-income countries. Read the article.
Treating aggressive ovarian cancer: current & emerging approaches
March 20, 2018: Oncology Times – This article discusses treatment planning, fighting recurrence, and improvement of outcomes. Read more.
Tumor-derived T cells show promise against ovarian cancer
March 16, 2018: Fierce Biotech – “A team of scientists from the Ludwig Institute for Cancer Research in Lausanne, Switzerland, found that epithelial ovarian tumors contain T cells that are particularly good at identifying and killing cancer cells. ” Read more.
FDA grants priority review to keytruda for advanced cervical cancer
March 16, 2018: Immuno-oncology News – “The decision marks the first time the FDA has accepted, and agreed to a priority review of, an anti-PD-1 therapy in cervical cancer, Merck said. PD-1 is a protein associated with many cancers.” Read more.
Common STD may double ovarian cancer risk
March 15, 2018: MSN – “Women who had chronic chlamydia infections had twice the risk of ovarian cancer compared to women with no evidence of ever having been infected, researchers are expected to report at a meeting of the American Association for Cancer Research in April.” Read more.
Laparoscopic hysterectomy safest even for markedly enlarged uteri
March 15, 2018: MDedge – “ according to findings from a nationwide cohort of more than 27,000 women.” Read more.
HPV screening results changed depending on test used
March 13, 2018: MedPage Today – “Human papillomavirus (HPV) messenger RNA (mRNA) assays may be less sensitive at detecting latent HPV infections, as women who previously tested positive for HPV via a DNA test then tested negative with mRNA testing, a quality-improvement study found.” Read more.
Dr. Crane on the toxicity profile of combinations for ovarian cancer
March 13, 2018: OncLive – “Erin K. Crane, MD, MPH, gynecologic oncologist, Levine Cancer Institute, Carolinas HealthCare System, discusses the toxicity profile of combination regimens for patients with ovarian cancer. When you combine cytotoxic chemotherapy drugs there tends to be a higher toxicity profile, but physicians are learning more about this from ongoing trials, explains Crane.” See the video interview.
Cancer treatment guidelines questioned in new study
March 8, 2018: CNN – “The strength of evidence referenced by the US-based group, referred to as the NCCN, when formulating guidelines and making recommendations appears to be weak, according to the study published in the journal BMJ on Wednesday.” Read more.
Ovarian cancer in T2D: no link between metformin or statins
March 5, 2018: Endocrinology Advisor – “In women with type 2 diabetes, no evidence was found of an association between the use of metformin or statins and the incidence of ovarian cancer, according to a study published in BJOG: An International Journal of Obstetrics and Gynaecology.” Read more.
How effective is peritoneal chemotherapy for ovarian cancer?
March 5, 2018: Medical News Bulletin – “A recent study in the Netherlands evaluated whether the standard treatment or intraperitoneal chemotherapy for ovarian cancer is the favourable treatment option.” Read more.
Australia could become first country to eradicate cervical cancer
March 3, 2018: The Guardian: “Australia could become the first country to eradicate cervical cancer, according to an announcement from the International Papillomavirus Society. New research, published on Sunday, reveals that Australia’s free HPV vaccine program in schools has led to a dramatic decline in future cervical cancer rates.” Read more.
Here’s how viruses inactivate the immune system, causing cancer
March 2, 2018: Science Daily – “While viruses certainly have the ability to edit human DNA — most obviously by inserting their own genetic code into DNA so that the new viruses are built alongside DNA replication — the review article explains that viruses do not necessarily turn off the immune system by editing genes.” Read more.
Potent anti-cancer drug effect in rare ovarian cancer
March 1, 2018: Science Daily – “An anti-cancer drug used to fight leukemia shows promise against a rare and aggressive type of ovarian cancer — small cell carcinoma of the ovary hypercalcemic type (SCCOHT) — which strikes young women and girls, according to a new study.” Read more.
Managing cancer pain in an era or modern oncology
March 2018: Practical Pain Management – ” A review of current, evolving, and needed strategies for treating cancer patients living with chronic pain. Read more.
Ovarian Cancer Case Study
February 28, 2018: Targeted Oncology – “In this case-based interview, Bradley J. Monk, MD, FACOG, FACS, reviews the case of a 40-year-old Caucasian female patient who presents with platinum-sensitive recurrent ovarian cancer and the treatment approach for this type of patient.” See more.
Use of intrauterine devices may reduce cervical cancer risk
February 28, 2018: Healio – “The use of an intrauterine device appeared associated with a significant decrease in invasive cervical cancer incidence, according to study findings.” Read more.
Familial breast cancer not only inherited genetically, finds new study
February 28, 2018: Science Daily – “Doctors will be better able to predict breast cancer risk thanks to pioneering work by researchers, who have identified heritable but non-genetic markers for breast cancer susceptibility.” Read more.
CIN2 regression rates underestimated – active surveillance better than excision for some patients
February 28, 2018: MedPage Today – “More untreated cervical intraepithelial neoplasia grade 2 lesions (CIN2) than previously thought regress spontaneously, making it “of utmost importance” to treat only those patients at significant risk of progressive disease, according to researchers.” Read more.
Cervical cancer immunotherapy candidate launches phase 3 study
February 26, 2018: Precisionvaccinations.com – “AIM2CERV cervical cancer vaccine study is to compare the disease-free survival rate of women who take AXAL.” Read more.
5-year overall survival in endometrial cancer not improved with chemoradiotherapy
February 22, 2018: Oncology Nurse Advisor – “Adjuvant chemotherapy administered concurrently with and after radiotherapy does not prolong 5-year overall survival (OS) among patients with high-risk endometrial cancer, according to a study published in The Lancet Oncology.” Read more.
Patients, caregivers express need for improved survivorship care in gynecologic oncology
February, 21, 2018: Journal of Clinical Pathways – “Widespread recommendation of survivorship care plans has occurred over the past decade. However, evidence-based content and processes for providing survivorship care planning—particularly in gynecologic oncology—remains undefined.” Read more.
Oncologist critical in motivating cancer survivors to exercise
February 20, 2018: Medscape – “Survivors may be more motivated to change their behavior when the advice comes from their oncologist…patients tended to be more physically active when the exercise recommendation came from their treating oncologist.” Read more.
The rs1024611 in the CCL2 gene and risk of gynecologic cancer in Asians: a meta-analysis
February 20, 2018: World Journal of Surgical Oncology – “The -2518A/G (rs1024611) polymorphism of the CCL2 (C-C motif chemokine ligand 2), also known as MCP-1 (monocyte chemotactic protein-1) gene, has been reported to be associated with increased gynecological cancer risk, but the results are conflicting.” Read the full article.
Doctors said immunotherapy would not cure her cancer. They were wrong.
February 19, 2018: New York Times – “If researchers can figure out what happened here, they may open the door to new treatments for a wide variety of other cancers thought not to respond to immunotherapy.” Read more.
Self-sampling followed by HVP testing can benefit women at risk of cervical cancer
February 16, 2018: Using self-sampling followed by HPV testing, more than twice as many women at risk of developing cervical cancer could be identified and offered preventive treatment. Read more.
IRX Therapeutics announces initiation of phase 2 clinical trial in IRX-2 in squamous cervical or vulvar intraepithelial neoplasia 3
February 14, 2018: Business Wire – “the first patient has been dosed in an investigator-sponsored Phase 2 double-blind, randomized, placebo-controlled clinical trial of IRX-2 in women with squamous cervical intraepithelial neoplasia 3 (CIN3) or vulvar intraepithelial neoplasia 3 (VIN3).” Read more.
Cutting off cancer’s fuel supply stymies tumors
February 14, 2018: Science Daily – “Researchers have shown that cervical tumors that don’t respond to radiation may be vulnerable to therapies that also attack the cancer’s fuel supply.” Read more.
FDA approves test to identify women with icreased risk for cervical cancer
February 13, 2018: Cure Today – “BD Onclarity HPV Assay, a test that can detect up to 14 types of high-risk human papillomavirus (HPV) and provides information on women who are at risk for cervical cancer, received pre-market approval from the Food and Drug Administration (FDA), according to a press release by Betcon, Dickinson and Company, the New Jersey-based manufacturer of the test.” Read more.
Dr. Arend on the rationale of novel combinations in gynecologic cancer
Festbruary 10, 2018: Onc Live – “Patients with gynecologic cancer who respond to single-agent immunotherapy have a high number of tumor infiltrating lymphocytes (TILs). However, a patient also needs the right antibodies, such as CD137 or CD103. According to Arend, those T cells can become exhausted and will stop responding to immunotherapy.” See her interview.
Olaparib maintenance therapy prolongs PFS for BRCA-mutated ovarian cancer
February 2, 2018: Healio – “Olaparib tablets significantly prolonged PFS compared with placebo among patients with BRCA1/BRCA2-positive high-grade serous ovarian cancer, according to results of the randomized phase 3 SOLO2/ENGOT Ov-21 clinical trial.” Read more.
Antidepressants may not increase ovarian cancer risk
February 1, 2018: Cancer Therapy Advisor – “Duration and intensity of antidepressant treatment does not have an impact on epithelial ovarian cancer risk, according to research published in the British Journal of Clinical Pharmacology.” Read more.
The end of toxic chemo? Blocking vitamin B-2 may stop cancer
January 31, 2018: Medical News Today – “New research published in the journal Aging finds a compound that stops cancer cells from spreading by starving them of vitamin B-2. The findings may revolutionize traditional chemotherapy.” Read more.
Dr. Coleman on the role of ramucirumab in gynecologic cancer
January 29, 2018: Onc Live – “Although ramucirumab is not being looked at in ovarian cancer, in endometrial, ovarian, and cervical cancers, that receptor seems to be important and continues to be investigated.” Read more.
Should all women be tested for breast, ovarian cancer gene mutations?
January 26, 2018: Healthline – “Researchers say testing women age 30 and over would reduce the number of breast and ovarian cancer cases.” Read more.
Calls of 3 advanced cancers die with drug-like compounds that reverse chemo failure
January 23, 2018: Science Daily – “Wet-lab experiments confirm the accuracy of an earlier computational discovery that three drug-like compounds successfully penetrate micro-tumors of advanced cancers to aid chemo in destroying the cancer.” Read the article.
Eight cancers could be diagnosed with a single blood test
January 19, 2018: Medical News Today – “The new blood test works by identifying the markers for 16 gene mutations and eight proteins that are associated with eight different cancer types. These include breast, lung, and colorectal cancer, as well as five cancers — ovarian, liver, stomach, pancreatic, and esophageal — for which there are currently no routine screening tests for people at average risk.” Read more.
Long-term birth control use reduces risk for ovarian, endometrial cancers
January 19, 2018: Healio – “More than 10 years of oral contraceptive use appeared associated with significant reductions in risk for ovarian and endometrial cancers, according to data published in JAMA Oncology.” Read more.
New therapies for endometrial cancer treatment
January 17, 2018: Medical News Bulletin – “A recent study published in Gynecologic Oncology Research and Practice reviews suggested endometrial cancer treatment options.” Read more.
Heated abdominal chemo bath improves ovarian cancer survival
January 17, 2018: Reuters – “A heated chemotherapy organ bath circulated throughout the abdomen after surgery can significantly prolong a woman’s survival with advanced ovarian cancer, according to doctors testing the new treatment.” Read more.
Preoperative imaging remains integral to endometrial cancer diagnosis
January 15, 2018: Onc Live – “An observational study is investigating the efficacy of PET/MRI in detecting metastatic disease in patients with endometrial cancer. The aim of this trial is to determine whether PET/MRI imaging will provide physicians with preoperative information about specific sites in the body where disease is present.” Read more.
Endometriosis may share molecular features with gynecological cancers, study finds
January 10, 2018: Compared to healthy women, patients with endometriosis have higher blood levels of a molecule that is linked to gynecological cancers, researchers from Taiwan report.
Peripheral neurotoxicity in gynecologic oncology patients who received paclitaxel
January 9, 2018: Pharmacy & Pharmacology International Journal – “60.6%of the patients who received paclitaxel reported sensory neurotoxicity which became worse after 2 cycles whereas a minority of the patients reported motor impairment.” Read the full article.
Study shows brachytherapy for cervical cancer a net loss for hospitals
January 5, 2018: Oncology Times – “The evidence is clear: cervical cancer is best treated with brachytherapy. Yet the use of this potentially lifesaving treatment has been declining, and a new study from the University of Virginia School of Medicine (UVA), Charlottesville, may explain why. Read more.
Researcher describe key cellular receptor involved in ovarian cancer metastasis
January 4, 2018: News Medical – “The IDIBELL-ICO research team has succeeded in associating the expression of the CXCR4 receptor in ovarian tumor cells to their dissemination potential through the bloodstream. CXCR4 is a receptor involved in blood cell movement, which had previously been related to processes of dissemination in breast cancer.” Read more.
Anti-estrogenic drugs can stablilise cervical cancer, shows research
January 4, 2018: Deccan Herald: “The study by a group of doctors from Kidwai Memorial Institute of Oncology, Institute of Bioinformatics and Applied Biotechnology (IBAB) and Shodhaka Life Sciences Private Limited through lab tests proved that the cancerous cells in cervical cancer patients can be stabilised with anti-estrogenic drugs. This drug suppresses the cancerous cells in patients.” Read more.
Hysterectomy with ovarian conservation tied to CV risks
January 3, 2018: MedPage Today – “Women who underwent a hysterectomy with ovarian conservation may be at greater risk for several cardiometabolic conditions, researchers reported.” Read more.
Aivita launches phase 2 trial of dendritic cell immunotherapy for ovarian cancer
January 3, 2018: Ovarian Cancer News Today: “Aivita Biomedical has initiated a Phase 2 trial of a new kind of dendritic cell immunotherapy for certain types of ovarian cancer. The therapy uses a patient’s own dendritic cells, which are boosted to fight the tumor by exposure to tumor proteins.” Read more.
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