Uterine/Endometrial Cancer (GTD & Sarcoma)

Endometrial cancer is a type of cancer that begins in the uterus, the hollow, pear-shaped pelvic organ in women where fetal development occurs. Endometrial cancer begins in the layer of cells that form the lining (endometrium) of the uterus. Other types of cancer can form in the uterus, including u
Endometrial cancer is often detected at an early stage because it frequently produces abnormal vaginal bleeding, which prompts women to see their doctors. Signs and symptoms of endometrial cancer may include:
  • Vaginal bleeding after menopause
  • Bleeding between periods
  • An abnormal, watery or blood-tinged discharge from your vagina
  • Pelvic pain
Doctors don't know what causes endometrial cancer. What's known is that something occurs to create a genetic mutation within cells in the endometrium — the lining of the uterus. The genetic mutation turns normal, healthy cells into abnormal cells. Healthy cells grow and multiply at a set rate, eventually dying at a set time. Abnormal cells grow and multiply out of control, and they don't die at a set time. The accumulating abnormal cells form a mass (tumor). Cancer cells invade nearby tissues and can separate from an initial tumor to spread elsewhere in the body (metastasize).
Options for treating endometrial cancer will depend on the characteristics of cancer, such as the stage, the patient’s general health and preferences. If endometrial cancer is discovered early, removing the uterus surgically often cures endometrial cancer. Other treatments include radiation therapy, chemotherapy, hormone therapy and biologic therapy. New types of targeted therapy are being tested in clinical trials. Please visit the National Cancer Institute (NCI) for more detailed treatment information about uterine cancer.
The Centers for Disease Control and Prevention (CDC) provides information, US statistics, and resources related to uterine cancer. Globe-athon to End Women's Cancer offers a collection of educational video lectures for the general public in which experts cover a variety of topics related to women's cancer. The National Cancer Institute is a reliable source for in-depth information about many cancers including prevention, screening, treatment and research for uterine cancer.
Global Cancer Observatory 2018 Fact Sheet on worldwide incidence, mortality and prevalence of ovarian cancer. The Global Cancer Observatory  is an interactive web-based platform presenting global cancer statistics to inform cancer control and research.  It uses data from the International Agency for Research on Cancer which is a specialized agency of the World Health Organization.