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The IGCS Education360 Podcast features interview segments with international leading experts discussing the latest advances and updates in gynecologic cancer therapeutics, surgery, and applications to clinical practice. The contributors provide commentary on the latest data from clinical trials and give their opinion on what the data means regarding potential treatment options and identify knowledge gaps requiring further research.

Ep. 1: The ABCs of ADCs

Antibody-Drug Conjugates (ADCs) are a class of biopharmaceutical drugs designed as a targeted therapy for treating cancer. Unlike chemotherapy, ADCs are intended to target and kill tumor cells while sparing healthy cells. In this episode you will learn the following:

  • How exactly do ADCs work?
  • What are the targets for ADCs?
  • What are the differences between ADC, MOA, and the differences in some of the ADCs – high DAR, and the controlled bystander effect
  • The importance of an optimal diagnostic assay (H-score vs PS2+ vs TPS) NS
  • The importance of a correct dosing regimen
  • The payload in relation to ADC’s and current ongoing studies.

Featured on this episode:
Dr. Brad Monk
Division of Gynecologic Oncology, Arizona Oncology (US Oncology Network) and the University of Arizona College of Medicine, Creighton University School of Medicine at St. Joseph's Hospital Phoenix, USA and Medical Director US Oncology Research Network - Gynecologic Program

Dr. Kathleen Moore
Virginia Kerley Cade Endowed Chair in Cancer Developmental Therapeutics Associate Director Clinical Research, Director, Oklahoma TSET Phase I Program, Stephenson Cancer Center and Associate Professor, Section of Gynecologic Oncology At the University of Oklahoma Health Sciences Center